Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Wt1  WT1 transcription factor   (Synonyms: D630046I19Rik, Wilms tumor 1 homolog, Wt-1)
Results	Reference
1	J:170930 Asahina K, Zhou B, Pu WT, Tsukamoto H, Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology. 2011 Mar;53(3):983-95
1	J:328231 Astanina E, Doronzo G, Cora D, Neri F, Oliviero S, Genova T, Mussano F, Middonti E, Vallariello E, Cencioni C, Valdembri D, Serini G, Limana F, Foglio E, Ballabio A, Bussolino F, The TFEB-TGIF1 axis regulates EMT in mouse epicardial cells. Nat Commun. 2022 Sep 3;13(1):5191
1	J:311885 Bandiera R, Vidal VP, Motamedi FJ, Clarkson M, Sahut-Barnola I, von Gise A, Pu WT, Hohenstein P, Martinez A, Schedl A, WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland. Dev Cell. 2013 Oct 14;27(1):5-18
1*	J:229936 Cano E, Carmona R, Ruiz-Villalba A, Rojas A, Chau YY, Wagner KD, Wagner N, Hastie ND, Munoz-Chapuli R, Perez-Pomares JM, Extracardiac septum transversum/proepicardial endothelial cells pattern embryonic coronary arterio-venous connections. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):656-61
1	J:304944 Carmona R, Barrena S, Lopez Gambero AJ, Rojas A, Munoz-Chapuli R, Epicardial cell lineages and the origin of the coronary endothelium. FASEB J. 2020 Apr;34(4):5223-5239
1	J:238024 Carmona R, Canete A, Cano E, Ariza L, Rojas A, Munoz-Chapuli R, Conditional deletion of WT1 in the septum transversum mesenchyme causes congenital diaphragmatic hernia in mice. Elife. 2016 Sep 19;5:e16009
1	J:225062 Chen SR, Zheng QS, Zhang Y, Gao F, Liu YX, Disruption of genital ridge development causes aberrant primordial germ cell proliferation but does not affect their directional migration. BMC Biol. 2013;11:22
1	J:208428 Chu JY, Sims-Lucas S, Bushnell DS, Bodnar AJ, Kreidberg JA, Ho J, Dicer function is required in the metanephric mesenchyme for early kidney development. Am J Physiol Renal Physiol. 2014 Apr;306(7):F764-72
1	J:301645 Cleal L, McHaffie SL, Lee M, Hastie N, Martinez-Estrada OM, Chau YY, Resolving the heterogeneity of diaphragmatic mesenchyme: a novel mouse model of congenital diaphragmatic hernia. Dis Model Mech. 2021 Jan 26;14(1)
1	J:231985 Delgado I, Carrasco M, Cano E, Carmona R, Garcia-Carbonero R, Marin-Gomez LM, Soria B, Martin F, Cano DA, Munoz-Chapuli R, Rojas A, GATA4 loss in the septum transversum mesenchyme promotes liver fibrosis in mice. Hepatology. 2014 Jun;59(6):2358-70
1	J:313609 Diaz Del Moral S, Barrena S, Hernandez-Torres F, Aranega A, Villaescusa JM, Gomez Doblas JJ, Franco D, Jimenez-Navarro M, Munoz-Chapuli R, Carmona R, Deletion of the Wilms' Tumor Suppressor Gene in the Cardiac Troponin-T Lineage Reveals Novel Functions of WT1 in Heart Development. Front Cell Dev Biol. 2021;9:683861
1	J:213513 Gao Y, Toska E, Denmon D, Roberts SG, Medler KF, WT1 regulates the development of the posterior taste field. Development. 2014 Jun;141(11):2271-8
1	J:263271 Haque F, Rancic V, Zhang W, Clugston R, Ballanyi K, Gosgnach S, WT1-Expressing Interneurons Regulate Left-Right Alternation during Mammalian Locomotor Activity. J Neurosci. 2018 Jun 20;38(25):5666-5676
1*	J:315261 Hsu WH, Yu YR, Hsu SH, Yu WC, Chu YH, Chen YJ, Chen CM, You LR, The Wilms' tumor suppressor Wt1 regulates Coronin 1B expression in the epicardium. Exp Cell Res. 2013 Jun 10;319(10):1365-81
1	J:314126 Jiang H, Song S, Li J, Yin Q, Hu S, Nie Y, Establishment and characterization of an immortalized epicardial cell line. J Cell Mol Med. 2021 Apr 6;
1	J:177490 Jongbloed MR, Vicente-Steijn R, Douglas YL, Wisse LJ, Mori K, Yokota Y, Bartelings MM, Schalij MJ, Mahtab EA, Poelmann RE, Gittenberger-De Groot AC, Expression of Id2 in the second heart field and cardiac defects in Id2 knock-out mice. Dev Dyn. 2011 Nov;240(11):2561-77
1	J:181719 Katoh-Fukui Y, Miyabayashi K, Komatsu T, Owaki A, Baba T, Shima Y, Kidokoro T, Kanai Y, Schedl A, Wilhelm D, Koopman P, Okuno Y, Morohashi K, Cbx2, a polycomb group gene, is required for Sry gene expression in mice. Endocrinology. 2012 Feb;153(2):913-24
1	J:253729 Kelder TP, Duim SN, Vicente-Steijn R, Vegh AM, Kruithof BP, Smits AM, van Bavel TC, Bax NA, Schalij MJ, Gittenberger-de Groot AC, DeRuiter MC, Goumans MJ, Jongbloed MR, The epicardium as modulator of the cardiac autonomic response during early development. J Mol Cell Cardiol. 2015 Dec;89(Pt B):251-9
1	J:168643 Kusaka M, Katoh-Fukui Y, Ogawa H, Miyabayashi K, Baba T, Shima Y, Sugiyama N, Sugimoto Y, Okuno Y, Kodama R, Iizuka-Kogo A, Senda T, Sasaoka T, Kitamura K, Aizawa S, Morohashi K, Abnormal epithelial cell polarity and ectopic epidermal growth factor receptor (EGFR) expression induced in Emx2 KO embryonic gonads. Endocrinology. 2010 Dec;151(12):5893-904
1	J:241636 Li J, Miao L, Zhao C, Shaikh Qureshi WM, Shieh D, Guo H, Lu Y, Hu S, Huang A, Zhang L, Cai CL, Wan LQ, Xin H, Vincent P, Singer HA, Zheng Y, Cleaver O, Fan ZC, Wu M, CDC42 is required for epicardial and pro-epicardial development by mediating FGF receptor trafficking to the plasma membrane. Development. 2017 May 01;144(9):1635-1647
1	J:237537 Liu C, Rodriguez K, Yao HH, Mapping lineage progression of somatic progenitor cells in the mouse fetal testis. Development. 2016 Oct 15;143(20):3700-3710
1	J:346139 Mah SYY, Vanyai HK, Li-Wai-Suen CSN, Garnham AL, Wynn J, Bergamasco MI, Malelang S, Wilcox S, Biben C, Smyth GK, Thomas T, Voss AK, ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development. Development. 2024 Mar 1;151(5):dev202617
1*	J:132132 Mahtab EA, Wijffels MC, Van Den Akker NM, Hahurij ND, Lie-Venema H, Wisse LJ, Deruiter MC, Uhrin P, Zaujec J, Binder BR, Schalij MJ, Poelmann RE, Gittenberger-De Groot AC, Cardiac malformations and myocardial abnormalities in podoplanin knockout mouse embryos: Correlation with abnormal epicardial development. Dev Dyn. 2008 Mar;237(3):847-57
1	J:166573 Martinez-Estrada OM, Lettice LA, Essafi A, Guadix JA, Slight J, Velecela V, Hall E, Reichmann J, Devenney PS, Hohenstein P, Hosen N, Hill RE, Munoz-Chapuli R, Hastie ND, Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin. Nat Genet. 2010 Jan;42(1):89-93
1	J:314041 Moazzen H, Venger K, Kant S, Leube RE, Krusche CA, Desmoglein 2 regulates cardiogenesis by restricting hematopoiesis in the developing murine heart. Sci Rep. 2021 Nov 4;11(1):21687
1	J:156690 Morimoto M, Liu Z, Cheng HT, Winters N, Bader D, Kopan R, Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate. J Cell Sci. 2010 Jan 15;123(Pt 2):213-24
1	J:92201 Natoli TA, Alberta JA, Bortvin A, Taglienti ME, Menke DB, Loring J, Jaenisch R, Page DC, Housman DE, Kreidberg JA, Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis. Dev Biol. 2004 Apr 15;268(2):429-40
1	J:227024 Paris ND, Coles GL, Ackerman KG, Wt1 and beta-catenin cooperatively regulate diaphragm development in the mouse. Dev Biol. 2015 Nov 1;407(1):40-56
1	J:336513 Patzek S, Liu Z, de la O S, Chang S, Byrnes LE, Zhang X, Ornitz DM, Sneddon JB, Loss of Fgf9 in mice leads to pancreatic hypoplasia and asplenia. iScience. 2023 Apr 21;26(4):106500
1*	J:111998 Reinholdt LG, Munroe RJ, Kamdar S, Schimenti JC, The mouse gcd2 mutation causes primordial germ cell depletion. Mech Dev. 2006 Jul;123(7):559-69
1	J:306614 Sasaki K, Oguchi A, Cheng K, Murakawa Y, Okamoto I, Ohta H, Yabuta Y, Iwatani C, Tsuchiya H, Yamamoto T, Seita Y, Saitou M, The embryonic ontogeny of the gonadal somatic cells in mice and monkeys. Cell Rep. 2021 May 4;35(5):109075
1*	J:186546 Scherptong RW, Jongbloed MR, Wisse LJ, Vicente-Steijn R, Bartelings MM, Poelmann RE, Schalij MJ, Gittenberger-De Groot AC, Morphogenesis of outflow tract rotation during cardiac development: The pulmonary push concept. Dev Dyn. 2012 Sep;241(9):1413-22
1	J:287023 Schnerwitzki D, Perry S, Ivanova A, Caixeta FV, Cramer P, Gunther S, Weber K, Tafreshiha A, Becker L, Vargas Panesso IL, Klopstock T, Hrabe de Angelis M, Schmidt M, Kullander K, Englert C, Neuron-specific inactivation of Wt1 alters locomotion in mice and changes interneuron composition in the spinal cord. Life Sci Alliance. 2018 Aug;1(4):e201800106
1	J:115344 Self M, Lagutin OV, Bowling B, Hendrix J, Cai Y, Dressler GR, Oliver G, Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. EMBO J. 2006 Nov 1;25(21):5214-28
1	J:119303 Seo S, Kume T, Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract. Dev Biol. 2006 Aug 15;296(2):421-36
1	J:325558 Torres-Cano A, Portella-Fortuny R, Muller-Sanchez C, Porras-Marfil S, Ramiro-Pareta M, Chau YY, Reina M, Soriano FX, Martinez-Estrada OM, Deletion of Wt1 during early gonadogenesis leads to differences of sex development in male and female adult mice. PLoS Genet. 2022 Jun;18(6):e1010240
1	J:217680 Trembley MA, Velasquez LS, de Mesy Bentley KL, Small EM, Myocardin-related transcription factors control the motility of epicardium-derived cells and the maturation of coronary vessels. Development. 2015 Jan 1;142(1):21-30
1*	J:284147 Velecela V, Torres-Cano A, Garcia-Melero A, Ramiro-Pareta M, Muller-Sanchez C, Segarra-Mondejar M, Chau YY, Campos-Bonilla B, Reina M, Soriano FX, Hastie ND, Martinez FO, Martinez-Estrada OM, Epicardial cell shape and maturation are regulated by Wt1 via transcriptional control of Bmp4. Development. 2019 Oct 17;146(20):dev178723
1	J:243174 Vicente-Steijn R, Scherptong RW, Kruithof BP, Duim SN, Goumans MJ, Wisse LJ, Zhou B, Pu WT, Poelmann RE, Schalij MJ, Tallquist MD, Gittenberger-de Groot AC, Jongbloed MR, Regional differences in WT-1 and Tcf21 expression during ventricular development: implications for myocardial compaction. PLoS One. 2015;10(9):e0136025
1	J:250600 Vieira JM, Howard S, Villa Del Campo C, Bollini S, Dube KN, Masters M, Barnette DN, Rohling M, Sun X, Hankins LE, Gavriouchkina D, Williams R, Metzger D, Chambon P, Sauka-Spengler T, Davies B, Riley PR, BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease. Nat Commun. 2017 Jul 24;8:16034
1	J:224386 Wainwright EN, Wilhelm D, Combes AN, Little MH, Koopman P, ROBO2 restricts the nephrogenic field and regulates Wolffian duct-nephrogenic cord separation. Dev Biol. 2015 Aug 15;404(2):88-102
1*	J:175398 Wei TC, Lin HY, Lu CC, Chen CM, You LR, Expression of Crip2, a LIM-domain-only protein, in the mouse cardiovascular system under physiological and pathological conditions. Gene Expr Patterns. 2011 Oct;11(7):384-94
1	J:102947 Wilm B, Ipenberg A, Hastie ND, Burch JB, Bader DM, The serosal mesothelium is a major source of smooth muscle cells of the gut vasculature. Development. 2005 Dec;132(23):5317-28
1	J:177189 Zeng B, Ren XF, Cao F, Zhou XY, Zhang J, Developmental patterns and characteristics of epicardial cell markers Tbx18 and Wt1 in murine embryonic heart. J Biomed Sci. 2011;18:67
1	J:320908 Zheng F, Chen Z, Tang QL, Wang XY, Chong DY, Zhang TY, Gu YY, Hu ZB, Li CJ, Cholesterol metabolic enzyme Ggpps regulates epicardium development and ventricular wall architecture integrity in mice. J Mol Cell Biol. 2021 Sep 11;13(6):445-454